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Objective:To evaluate the antidiabetic and hypolipidemie activities of ethanolic leaf extract and Fraction of Melanthera scandens(M.scandens) in alloxan-induced diabetic rats.Methods:M.scandens leaf extract/fractions(37-111 mg/kg) were administered to alloxan-induced diabetic rats for 14 days and blood glucose levels(BGL) of the diabetic rats were monitored at intervals of 7 hours for acute study and 14 days lor prolonged study.Lipid profiles of the treated diabetic rats were determined after the period of treatment.Results:Treatment of alloxan-induced diabetic rats with the extract/fractions caused a significant(P<0.001) reduction in lasting bloodglucose levels(BGL) ol the diabetic rats both in acute study and prolonged Irealnient(2weeks).The activities of the extract and fractions were more than that of the reference drug,glibenclamide.The extract/fractions exerted a significant reduction in the levels of serum total cholesterol,triglycerides,LDL and VLDL of extract with increases in HDL.levels of the diabetic rats.Conclusions:These results suggest that the leaf extract/fractions(AM.scandals possesses antidiabetic effect on alloxan induced diabetic rats and this justifies its use in ethno medicine and can be exploited in the management of diabetes.
Objective: To evaluate the antidiabetic and hypolipidemie activities of ethanolic leaf extract and Fraction of Melanthera scandens (M.scandens) in alloxan-induced diabetic rats. Methods: M.scandens leaf extract / fractions (37-111 mg / kg) were administered to alloxan-induced diabetic rats for 14 days and blood glucose levels (BGL) of the diabetic rats were monitored at intervals of 7 hours for acute study and 14 days lor prolonged study. Lipid profiles of the treated diabetic rats were determined after the period of treatment Results: Treatment of alloxan-induced diabetic rats with the extract / fractions caused a significant (P <0.001) reduction in lasting blood glucose levels (BGL) ol the diabetic rats both in acute study and prolonged Irealnient (2 weeks). Activities of the extract and fractions were more than that of the reference drug, glibenclamide.The extract / fractions exerted a significant reduction in the levels of serum total cholesterol, triglycerides, LDL and VLDL of extract with increases in HDL.levels of the diabetic rats. Conclusions: These results suggest that the leaf extract / fractions (AM. Scandals possesses antidiabetic effect on alloxan induced diabetic rats and this justifies its use in ethno medicine and can be exploited in the management of diabetes.