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本实验复制了甲亢小鼠模型,用皮下注射异丙基肾上腺素1.8 ug/10克体重后,以血浆中cAMP定量变化为指标观察了助阳药附桂合剂,滋阴益气药生芪合剂,滋阴药生地煎剂的作用。实验结果:经用异丙肾刺激后,甲亢组cAMP含量(630±40.53)(M±SE,pmol/ml)显著高于正常对照组(384±27.40)(P<0.001)。甲亢服附桂组,其血浆cAMP含量(979±72.14)明显高于甲亢对照组(P<0.01)。甲亢服生芪组,其血浆cAMP含量(409±38.09)明显低于甲亢对照组(P<0.01)。甲亢服生地组,其血浆cAMP含量(489±23.28)亦低于甲亢对照组(P<0.01)。实验结果表明甲亢小鼠的β受体系统对异丙肾的反应性呈现亢进状态,助阳药附桂合剂促进其反应性进一步提高,而滋阴益气药生芪合剂和滋阴药生地能降低其反应性。
In this experiment, a mouse model of hyperthyroidism was replicated. After subcutaneous injection of isoproterenol 1.8 ug/10 g body weight, the quantitative change of cAMP in plasma was used as an index to observe the effect of assisting Yangyin with Fugui Mixture and Ziyin Yiqi Yaosheng Mixture. , The role of decoction in nourishing yin medicine habitat. Experimental results: After being stimulated with isoproterenol, the cAMP content (630±40.53) (M±SE, pmol/ml) in the hyperthyroidism group was significantly higher than that in the normal control group (384±27.40) (P<0.001). In addition, the plasma cAMP content in hyperthyroidism was significantly higher (979±72.14) than that in the hyperthyroidism control group (P<0.01). In the hyperthyroidism group, the plasma cAMP level (409±38.09) was significantly lower than that of the hyperthyroidism control group (P<0.01). In the placebo group, the plasma cAMP content (489±23.28) was also lower than that of the control group (P<0.01). The experimental results showed that the hyperactivity of β-receptor system in hyperthyroidism mice showed a hyperactive response to isoproterenol, and the positive effect of Ziyang Yifu Mixture was further promoted. Reduce its reactivity.