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我们在实验性动脉粥样硬化(以下简称动粥)研究中观察到一个很恒定的现象,就是高脂饮食导至血脂升高、脂质内渗后,相当时期内内膜并无病变形成。动脉壁本身对内渗脂质如何转运和清除,迄今尚不十分清楚。关于脂质斑块形成前后内应通透性的变化,目前说法也不一至。探讨和弄清这些问题对于进一步阐明动粥的发病机理是非常重要的。为此,本文重点观察了通透性改变、脂质内渗以及在动脉壁内脂质转运清除和沉积间的动态关系。
We observed a very constant phenomenon in the experimental atherosclerosis (referred to as “dynamic porridge”) study. After the high-fat diet led to elevated blood lipids and lipid permeation, there was no lesion formation within a certain period of time. It is still not clear how the introgression of lipids is transported and cleared by the arterial wall itself. Changes in internal permeability before and after the formation of lipid plaques are currently not the same. To explore and clarify these issues is very important to further clarify the pathogenesis of moving porridge. For this reason, this article focuses on the dynamic relationship between permeability changes, lipid infiltration, and lipid transport clearance and deposition in the arterial wall.