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用高效液相色谱仪(HPLC)测定兔血及大肠组织内5-FU.兔经iv 5-FU和肠系膜下动脉注射(ia)5-FU 15mg/kg后血浓度及药-时曲线相似,但大肠组织中5-FU分布有别.ia组在注射5-FU后10,20,30min时大肠5-FU浓度分别为i v组的31,17及14倍.组织AUC分别为2453和690min·mg/ml.提示大肠癌病人在术间或术后由肠系膜下动脉注入5-FU可望提高疗效.
The blood concentrations and drug-time curves of 5-FU in rabbit blood and colorectal tissues were determined by high performance liquid chromatography (HPLC) after iv 5-FU and ia 5-FU 15 mg / kg, However, the distribution of 5-FU in colorectal tissue was different.The concentrations of 5-FU in colorectal mucosa of rats in group A were 31, 17 and 14 times of those in group iv respectively at 10, 20 and 30 min after injection of 5-FU.The tissue AUC were 2453 and 690 min · mg / ml, suggesting that patients with colorectal cancer surgery or postoperative injection of 5-FU from the inferior mesenteric artery is expected to improve the curative effect.