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新利尿剂—microx [Medical Letter 1988;30(768):63.(英文)] Microx是一种新的低剂量配方的噻嗪类利尿剂甲苯喹唑酮(metolazone),近来已在美国销售。制造者声称,低剂量microx能控制高血压,钾较少丢失,比其它利尿剂安全,疗效同组合利尿药,如dyazlde,即包括一种噻嗪类和保钾利尿药。药物动力学:本品从胃肠道吸收比其它metolazone更快、更完全。服药后2～4小时可达血清峰值。半衰期约为14小时。临床试验:对105例轻至中良高血压病患者进行了6周的双盲试验,比较3种量microx(0.5mg、1mg或2mg/日)与安慰剂
New Diuretics -microx [Medical Letter 1988; 30 (768): 63. (English)] Microx is a new low-dose thiazide diuretic, metolazone, recently marketed in the United States. Manufacturers claim that low-dose microx can control high blood pressure with less loss of potassium and is safe and effective than other diuretics in combination with diuretics such as dyazlde, which includes a thiazide and potassium-sparing diuretic. Pharmacokinetics: This product is absorbed from the gastrointestinal tract faster and more completely than other metolazone. 2 to 4 hours after taking serum peak. Half-life is about 14 hours. Clinical Trial: Sixty-five double-blind trials of 105 patients with mild to moderate essential hypertension were performed and compared with 3 doses of microx (0.5 mg, 1 mg or 2 mg / day) and placebo