论文部分内容阅读
目的对孕妇进行孕中期产前筛查能筛查出染色体异常和各种神经管畸形的胎儿,经确诊后可中止妊娠,有利于优生。方法采用贝克曼ACCESS全自动免疫分析仪对1520例孕中期孕妇血清进行甲胎蛋白(AFP)、β绒毛膜促性腺激素(β-HCG)及游离雌三醇(u-E3)的检测,采用分析软件计算唐氏综合征(DS)、18三体综合征、神经管畸形(NTD)风险率。结果 DS筛查阳性72例,高危率4.74%,经随访60例做确诊检查,DS阳性1例,18三体阳性1例;NTD筛查阳性25例,高危率1.6%,5例经B超检查确诊为神经管畸形。结论孕妇孕中期进行产前筛查,减少出生缺陷,对优生优育工作具有重要意义。
OBJECTIVE To screen pregnant women with fetuses with chromosomal abnormalities and various neural tube defects during the second trimester of pregnancy by prenatal screening. Pregnancy can be terminated after diagnosis, which is good for eugenics. Methods The serum levels of AFP, β-HCG and u-E3 in 1520 pregnant women of the second trimester were detected by Beckman ACCESS automatic immunoassay analyzer. Analysis software calculates the risk of Down Syndrome (DS), Trisomy 18, and Neural Tube Defects (NTD). Results 72 cases were positive for DS screening and the high-risk rate was 4.74%. One case of DS positive and one case of 18 trisomy 18 were confirmed by follow-up of 60 cases. The positive rate of NTD screening was 25 cases, the high-risk rate was 1.6% Check the diagnosis of neural tube defects. Conclusion Pregnant women during the second trimester screening prenatal to reduce birth defects, the eugenics is of great significance.