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目的:探索气虚血瘀证动物模型的制作方法。方法:采用“饥饿+高脂+肾上腺素”复合多因素制备气虚血瘀证模型。结果:模型组家兔表现为蜷缩少动、精神不振、爪尾部紫暗等症状;血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)显著升高、血浆内皮素(ET)升高,血管紧张素II(AngII)升高,与正常组及对照组比较有显著性差异。结论:上述方法建立气虚血瘀证家兔模型,符合中医证侯特点,具有一定的理论和实践意义。
Objective: To explore the method of making animal model of qi deficiency and blood stasis. Methods: The Qi-deficiency and blood-stasis syndrome model was prepared by the combination of “starvation + hyperlipidemia + epinephrine” and multiple factors. Results: The rabbits in the model group showed less curl, lack of energy, dark purple tail and other symptoms. The contents of TC, TG and LDL-C in serum of the model group were significantly increased , Plasma endothelin (ET) increased, angiotensin II (AngII) increased, compared with the normal group and the control group were significantly different. Conclusion: The above method to establish a rabbit model of qi deficiency and blood stasis, in line with the characteristics of TCM card Hou, has some theoretical and practical significance.