论文部分内容阅读
钙拮抗剂已被广泛地用于治疗心绞痛和高血压等心血管疾病。但它的严重药物不良反应，在近１０年的大规模临床试验中，也逐渐被人们所认识，尤其是短效双氢吡啶类钙拮抗剂。长效制剂无此药物不良反应。本文就目前钙拮抗剂大剂量长期使用增加死亡率，致心肌缺血，诱发出血，血压过低，负性肌力作用和诱发心律失常等，及钙拮抗剂对缺血心肌的保护作用进行讨论，认为它不具有细胞保护作用，而是通过改变血流动力学，对缺血心肌的改善起一定作用；还认为其药物不良反应与剂量呈正相关。
Calcium antagonists have been widely used in the treatment of cardiovascular diseases such as angina pectoris and hypertension. However, its serious adverse drug reactions have gradually been recognized in large-scale clinical trials in recent 10 years, especially short-acting dihydropyridine calcium antagonists. Long-acting agents without this drug adverse reactions. In this paper, the current large doses of calcium antagonists increased mortality, caused by myocardial ischemia, induced bleeding, hypotension, negative inotropic effect and induced arrhythmia, and calcium antagonists on the protective effect of ischemic myocardium , That it does not have a cytoprotective effect, but by changing the hemodynamics, play an important role in the improvement of ischemic myocardium; also considered the adverse drug reactions and dose was positively correlated.