论文部分内容阅读
鞭毛四膜虫的核rRNA前体可在没有蛋白质的离体情况下进行准确的RNA拼接。发现RNA自身拼接普遍性的第一个线索是四膜虫rRNA内含于与酵母菌及其它真菌线粒体的许多mRNA和rRNA内含子都有一套共同的基因序列。这些线粒体子内含子曾根据其保守序列的成分分归为第一组内含子,并认为这些保守成分的相互作用使内含子折叠成相同核心的二级结构。这些保
The nuclear rRNA precursor of Tetrahymena flagellum can be spliced accurately without RNA in vitro. The first clues to discover the universality of RNA itself splicing is that Tetrahymena rRNA contains a common set of gene sequences contained in many mRNAs and rRNA introns of yeast and other fungal mitochondria. These mitochondrial introns have been grouped into the first set of introns based on their conserved sequence components and the interaction of these conserved components is thought to fold the introns into secondary core structures of the same core. These blessings