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目的:调查北京山区学龄儿童机体铁状况、亚临床铁缺乏患病率及观察采用EDTA钠铁间断补充与早期铁干预效果,为缺铁性贫血的综合防治提供依据。方法:对北京房山山区1018名6～14岁学龄儿童进行膳食调查、膳食频率调查与铁生化指标检测,依现行标准筛检贮存铁减少(ID)、红细胞生成缺铁(IDE)和缺铁性贫血(IDA)儿童。给予口服乙二胺四乙酸钠铁(NaFeEDTA)胶囊(每粒含元素铁60mg),每次1粒,JD与IDE儿童,每周1次,IDA儿童每周3次,连续9周,重复测定铁生化指标,并与干预前进行比较。结果:各年龄组儿童能量、蛋白质、铁和维生素C平均每日摄入量基本达到推荐的膳食营养素摄入量(RNI),但膳食铁构成中血红素铁所占比例较低;该人群血液铁生化指标检测平均值为SF(50.83±33.09)μg/L,FEP(0.88±0.40)μmol/L,FEP/Hb(x10~2)(0.87±0.45),Hb(130.57±10.82)g/L;总铁缺乏检出率为26.5%,其中ID占15.5%,IDE占7.2%,IDA占3.9%,亚临床铁缺乏(ID+IDE)占缺铁总人数的85.4%,为IDA的5.8倍;采用本研究中的铁干预方法后,各项铁指标显著提高并恢复至正常水平。结论:该人群铁缺乏检出率为26.5%,亚临床缺铁占总缺铁的85.4%,为IDA的5.8倍,亚临床铁缺乏是一个值得重视的隐匿人群,采取早期鉴定、干预与综合防治对降低其患病率、改善健康状况有重要意义。
Objective: To investigate the body iron status, the prevalence of subclinical iron deficiency in school-age children in Beijing mountainous areas and to observe the effect of intermittent iron-EDTA supplementation and early iron intervention to provide a basis for the comprehensive prevention and treatment of iron-deficiency anemia. Methods: A total of 1018 school-age children aged 6-14 years in Fangshan mountain area of Beijing were investigated for dietary frequency, dietary frequency and iron biochemical indexes. According to the standard screening, the iron deficiency (ID), iron deficiency of erythrocytes (IDE) and iron deficiency Anemia (IDA) children. Oral administration of NaFeEDTA capsules (each containing 60 mg of elemental iron), 1 tablet each time, JD and IDE children once a week, IDA children 3 times a week for 9 consecutive weeks, and repeated measurements Iron biochemical indicators, and compared with the pre-intervention. Results: The average daily intake of energy, protein, iron and vitamin C in children of all ages basically reached the recommended intake of dietary nutrients (RNI), but the proportion of heme iron in the composition of dietary iron was lower. The blood The mean values of biochemical parameters of iron were SF (50.83 ± 33.09) μg / L, FEP (0.88 ± 0.40) μmol / L, FEP / Hb x10 ~ 2 0.87 ± 0.45 and Hb 130.57 ± 10.82 g / . The detection rate of total iron deficiency was 26.5%, ID was 15.5%, IDE was 7.2%, IDA was 3.9%, subclinical iron deficiency (ID + IDE) accounted for 85.4% of total iron deficiency, 5.8 times that of IDA ; Using the iron intervention method in this study, the iron indicators significantly increased and returned to normal levels. Conclusion: The detection rate of iron deficiency in this population is 26.5%, sub-clinical iron deficiency accounts for 85.4% of total iron deficiency, which is 5.8 times of that of IDA. Subclinical iron deficiency is a worthy concealed crowd. Early identification, intervention and synthesis Prevention and control to reduce its prevalence, improve health status is important.