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目的:探讨在心功能正常情况下不稳定心绞痛(UAP)与稳定型心绞痛(SAP)患者血浆N-末端脑钠肽前体(NT-proBNP)浓度的差异,UAP患者血浆NT-proBNP浓度与肌钙蛋白I(cTnI)的相关性。方法:选择住院冠心病心绞痛患者116例,其中SAP54例,UAP组62例(cTnI阳性者32例,阴性者30例),正常对照组35例,测定血浆NT-proBNP、cTnI浓度,比较不同组NT-proBNP浓度,及分析UAP患者NT-proBNP与cTnI的关系。结果:UAP患者血浆NT-proBNP浓度[146.55(53.65,772.55)ngP/L]高于SAP组[47.50(19.23,87.35)ngP/L]和对照组[33.38(14.07,66.60)ngP/L](P<0.01),SAP组血浆NT-proBNP浓度与对照组比较无显著差异(Z值-1.20,P>0.05),且UAP中cTnI阳性组血浆NT-proBNP浓度[646.86(127.85,1181.63)ngP/L]高于cTnI阴性组[91.50(26.54,145.83)ngP/L](Z值-3.96,P<0.01),UAP血浆NT-proBNP浓度与cTnI浓度呈正相关(r=0.57,P<0.05)。结论:UAP血浆NT-proBNP浓度增高,并与cTnI浓度呈正相关;其测定有利于发现心功能正常,但处于高风险的患者。
Objective: To investigate the difference of plasma N-terminal pro brain natriuretic peptide (NT-proBNP) concentrations in patients with unstable angina pectoris (UAP) and stable angina pectoris (SAP) under normal cardiac function. The correlation between plasma NT-proBNP and UA Correlation of protein I (cTnI). Methods: A total of 116 patients with coronary heart disease and angina pectoris were enrolled in this study. Among them, 54 cases were SAP54, UAP 62 cases (32 cTnI positive, 30 negative) and 35 cases of normal control group. Plasma concentrations of NT-proBNP and cTnI were measured, NT-proBNP concentration, and analyze the relationship between NT-proBNP and cTnI in patients with UAP. Results: The plasma concentration of NT-proBNP in patients with UAP [146.55 (53.65,772.55) ngP / L] was significantly higher than that in SAP patients [47.50 (19.23,87.35) ngP / L and 33.38 (14.07,66.60) ngP / L] (P <0.01). There was no significant difference in plasma NT-proBNP concentration between the SAP group and the control group (Z value -1.20, P> 0.05). The NT-proBNP concentration in the cTnI positive group was 646.86 (127.85,1181.63) ngP / L] was higher than that of cTnI negative group [91.50 (26.54,145.83) ngP / L] (Z value -3.96, P <0.01). The NT-proBNP concentration of UAP was positively correlated with the concentration of cTnI in rTNI group (r = 0.57, P <0.05). CONCLUSIONS: UAP plasma NT-proBNP concentration is elevated and positively correlated with cTnI concentration. It is beneficial to detect patients with normal cardiac function but high risk.