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1898-1907年,在第三次世界鼠疫大流行期间,鼠疫经马达加斯加的一些大港口城市传入.马尔加什疫源地栩当于该岛面积的15%,仅在这片陆地上,9月至次年4月一直有鼠疫活动.参与鼠疫流行的因素有三种:鼠疫菌亚种 Devignat orientalis、印鼠客蚤和黑家鼠.巴斯德研究所的鼠疫中心实验室分离并鉴定鼠疫菌株(1988年52株).对菌株质粒的毒力研究表明,从1940-1988年47Md 质粒的表达有规律的增加.人类抗鼠疫免疫力的研究表明免疫力高、早期发生且持久.用免疫印渍法作免疫研究发现,每个病人都有全身免疫和特异性免疫,而36kd 的外膜蛋白似乎起一种调理素的作用.总之,在马达加斯加,治疗鼠疫的进展和免疫是顺利的,但鼠疫未根除之前,紧急状况依然长期存在。
During the period from 1998 to 1907, the Plague was introduced by some large port cities in Madagascar during the third world outbreak. The Malagasy foothills are responsible for 15% of the island’s area, only on this land There have been three plague outbreaks since January to April, 2008. There are three factors involved in the plague epidemic: Devignat orientalis, rat fleas and black house rats Pasteur’s laboratory in the Pasteur Laboratory Isolates and identifies plague strains (52 strains in 1988) .Studies on virulence of strain plasmid showed that the expression of 47Md plasmid increased regularly from 1940 to 1988. Studies on human anti-plague immunity showed high immunity, early occurrence and persistence. Staining Immunization Studies found that each patient had systemic and specific immunity, whereas the 36 kd outer membrane protein appeared to act as a opsonin.In summary, the progress and immunization of the plague in Madagascar was smooth, but Before the plague eradication, the emergency situation still exists for a long time.