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本文报道了ＨＩＴ４单抗对金黄色葡萄球菌ＣｏｗａｎⅠ菌体（ＳＡＣ）诱导的ＩｇＧ分泌的抑制效应．研究发现ＨＩＴ４单抗可明显抑制ＳＡＣ诱导的正常人和ＩＴＰ患者外周血单个核细胞（ＰＢＭＣ）分泌ＩｇＧ，平均抑制率分别为８１．４±１２．０％和９２．７±１２．８％，而对Ｉｇ分泌水平低下的新生儿脐血单个核细胞无调节作用。ＨＩＴ４单抗的抑制作用是通过ＨＩＴ４＋细胞表面ＨＩＴ４抗原特异性介导，选择地作用于ＳＡＣ（而不是ＰＷＭ）诱导的ＩｇＧ分泌过程，具有剂量依赖性。本研究为了解ＨＩＴ４单抗的生物学特点及可能具有的临床应用前景提供了资料。
This article reports the inhibitory effect of HIT4 mAbs on IgG secretion induced by Staphylococcus aureus Cowan I (SAC). The study found that HIT4 monoclonal antibody could significantly inhibit the secretion of IgG from peripheral blood mononuclear cells (PBMCs) of normal and ITP patients induced by SAC, with the average inhibition rates of 81.4 ± 12.0% and 92.7 ± 12.8%, respectively, While the low level of Ig secretion of neonatal umbilical cord blood mononuclear cells no regulation. The inhibitory effect of HIT4 mAb was mediated by HIT4 antigen on HIT4 + cell surface selectively and selectively on the secretion of IgG induced by SAC (but not by PWM) in a dose-dependent manner. This study provides information for understanding the biological characteristics of HIT4 monoclonal antibody and possible clinical application prospects.