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目的：观察在全胃肠外营养（ＴＰＮ）时患者体内奈替米星（乙基西梭霉素，ＮＴＭ） 的药代动力学。方法：用高效液相间接光度检测法（ＨＰＬＣＩＰＤ） 测定７ 例行ＴＰＮ 患者和７ 例对照患者静滴ＮＴＭ５ｍｇ·ｋｇ－ １ 后血清和尿中药物浓度，并计算药代动力学参数。结果：ＮＴＭ 在体内处置符合二室开放模型，静滴后ＴＰＮ 组ＮＴＭ 血清峰浓度低于对照组但无显著性差异，至５ｈ 后ＴＰＮ组浓度开始高于对照组，至１２ｈ 时已明显高于对照组；尿中原型药物排出率ＴＰＮ 组较对照组下降，但无显著性差异；ＴＰＮ组与对照组血清ＮＴＭ 的ｔ１／２β分别为（５ ．８±１．６）ｈ 和（３．５±１．４）ｈ。结论：患者给ＴＰＮ时，ＮＴＭ 体内分布和消除变慢
OBJECTIVE: To investigate the pharmacokinetics of netilmicin (ethnomicin, NTM) in patients with total parenteral nutrition (TPN). Methods: Serum and urinary concentrations of NTM 5 mg · kg-1 were measured in 7 TPN patients and 7 control patients by HPLC-IPD. The pharmacokinetic parameters were calculated. Results: In NTM group, the concentration of NTM in TPN group was lower than that in control group after intravenous drip infusion. At 5h, the concentration of TPN group began to be higher than that of control group, which was significantly higher than that of control group (P <0.05). The TPN of urinary drug excretion rate was lower than that of the control group, but there was no significant difference. The t1 / 2β of serum NTM in TPN group and control group were (5. 8 ± 1.6) h and (3.5 ± 1.4) h. Conclusion: In patients with TPN, the distribution and elimination of NTM in the body slowed down