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目的:通过体外研究探讨化疗剂量对乳腺癌治疗效果的影响。方法:通过手术取材和肿瘤组织原代细胞体外培养技术,对96例乳腺癌患者进行体外药物敏感性检测。结果:乳腺癌晚期患者比早期患者的耐药风险明显增加(P<0.05),乳腺癌复发患者比原发患者具有更强的多药耐药能力(P<0.01);增加化疗药物剂量仍然可以提高大多数耐药患者的治疗效果(P<0.01)。结论:大剂量化疗方案对晚期和复发性乳腺癌患者有帮助。
Objective: To investigate the effect of chemotherapy dosage on the therapeutic effect of breast cancer in vitro. Methods: Ninety-six patients with breast cancer were tested for drug susceptibility by in vitro surgical techniques and in vitro culture of primary tumor cells. Results: The risk of drug resistance in patients with advanced breast cancer was significantly higher than that in patients with early-stage breast cancer (P <0.05), and patients with recurrent breast cancer had more multi-drug resistance than those in patients with primary breast cancer (P <0.01) Improve the therapeutic effect of most drug-resistant patients (P <0.01). Conclusions: High-dose chemotherapy regimens are helpful in patients with advanced and recurrent breast cancer.