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目的:探讨小儿川崎病心肌酶谱变化与冠脉损伤的关系。方法:回顾性分析武汉市妇女儿童医疗保健中心120例川崎病患儿的临床资料,根据检查分为有损伤组和无损伤组,同时选择正常患者为对照组,通过心肌酶谱检查和CRP检查,观察两者联系。结果:治疗前有损害组与无损害组心肌酶谱对比,各项均无统计学差异(P>0.05);对照组与有损害组及无损害组对比,CK-MB水平差异有统计学意义(P<0.05),其余各项均无统计学差异(P>0.05)。治疗前CRP、CK-MB水平与对照组相比,有统计学差异(P<0.05);治疗后CRP与对照组比较差异无统计学意义(P>0.05);CK-MB与对照组相比,差异有统计学意义(P<0.05)。结论:心肌酶谱中心肌酶同工酶在川崎病发生与缓解后,均可以有效反映心肌损害程度,可以作为诊断川崎病出现心肌损害与否的重要指标。
Objective: To investigate the relationship between changes of myocardial enzymes and coronary artery injury in children with Kawasaki disease. Methods: The clinical data of 120 children with Kawasaki disease in Wuhan Women’s and Children’s Medical Center were retrospectively analyzed. According to the examination, they were divided into injury group and non-injury group. Normal patients were selected as the control group. The myocardial enzymes and CRP , Observe the relationship between the two. Results: There was no significant difference in myocardial enzymes between pre-treatment and non-pre-treatment groups (P> 0.05). There was significant difference in CK-MB levels between the control group and the damaged and non-damaged groups (P <0.05), the rest of the no significant difference (P> 0.05). The levels of CRP and CK-MB before treatment were significantly lower than those of the control group (P <0.05). There was no significant difference between the two groups after treatment (P> 0.05). Compared with the control group , The difference was statistically significant (P <0.05). Conclusion: Myocardial zymogram myocardial enzyme isozymes in the occurrence and relief of Kawasaki disease can effectively reflect the degree of myocardial damage, Kawasaki disease can be used as a diagnosis of myocardial damage or not an important indicator.