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目的:检测热性惊厥患儿神经元特异性烯醇化酶(NSE)水平变化,了解其在惊厥发作以及预后的意义。方法:将120例热性惊厥患儿按惊厥发作情况分为单纯型和复杂型热性惊厥,分别检测他们在惊厥发生6 h内以及发作后72 h的NSE水平。结果:单纯型热性惊厥组发作后6 h血清NSE水平为(14.60±2.89)ng/ml,72 h血清NSE水平为(13.00±1.46)ng/ml,复杂型热性惊厥组发作后6 h血清NSE水平为(18.72±2.40)ng/ml,72 h血清NSE水平为(14.46±2.47)ng/ml,均显著高于对照组,差异有统计学意义(P<0.01)。复杂型热性惊厥组6 h血清NSE水平升高显著高于单纯型热性惊厥组,差异有统计学意义(P<0.01),但两者72 h血清NSE水平差异无显著性差异(P>0.05)。结论:NSE可以作为热性惊厥病情严重程度及预后的一项监测指标。
Objective: To detect the changes of neuron-specific enolase (NSE) in children with febrile seizures and to find out its significance in seizure and prognosis. Methods: One hundred and seventy children with febrile seizures were divided into simple and complex febrile seizures according to seizures. The levels of NSE in seizures within 6 hours and 72 hours after seizure were detected. Results: The serum levels of NSE were (14.60 ± 2.89) ng / ml at 6 h after onset of fever and 13.00 ± 1.46 ng / mL at 72 h in the febrile seizure group. The levels of NSE in the febrile seizure group at 6 h The level of NSE in serum was (18.72 ± 2.40) ng / ml, and the level of NSE in 72 h was (14.46 ± 2.47) ng / ml, which were significantly higher than those in control group (P <0.01). The level of serum NSE in the complicated febrile convulsion group at 6 h was significantly higher than that in the simple febrile seizure group (P <0.01), but there was no significant difference in serum NSE level between the two groups at 72 h (P> 0.05). Conclusion: NSE can be used as a monitoring indicator of the severity and prognosis of febrile seizures.