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本文采用高效液相色谱法建立了血浆中黄豆甙元的含量测定方法,研究了黄豆甙元及其固体分散物在人体内的生物利用度并求得药物动力学有关参数。结果表明黄豆甙元固体分散物胶囊相对市售胶囊的相对生物利用度为504%.
In this paper, HPLC was used to determine the content of daidzein in plasma. The bioavailability of daidzein and its solid dispersions in human was studied and the pharmacokinetic parameters were obtained. The results showed that the relative bioavailability of daidzin solid dispersion capsules relative to commercial capsules was 504%.