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Objective:To investigate association between glutathione S-transferases(GSTs) and cervical cancer.Methods:Published literature from PubMed,EMBASE,and other databases were retrieved.All studies evaluating the association between GSTM l/GSTTl polymorphisms and cervical were included.Pooled odds ratio(OR) and 95%confidence interval(CI) were calculated using fixed- or random-effects model.Results:A total of 15 case-control studies were included in the meta-analysis of GSTM1 genotypes(1825 cases and 2 104 controls).The overall result showed that the association between GSTM 1 null genotype and risk for cervical cancer was statistically significant(OR= 1.53,95%CI= 1.18-2.00).Great heterogeneity was found between studies.Subgroup analysises were performed based on smoking and ethnicity.Our results showed that smokers with null CSTM1 genotype had higher risk of cervical cancer(0R=1.56,95%CI=l.01- 2.41).For the ethnicity stratification,significant increased risk of null GSTM1 genotype was found in Chinese and Indian population,but no increased risk in other population.Conclusions:This meta-analysis provides strong evidence that the GSTM1 null genotype is associated with the development of cervical cancer,and especially in Chinese and Indian population,and smoking shows a modification on the association between GSTM 1 null genotype and cervical cancer.