论文部分内容阅读
乙胺碘呋酮(Amiodarone,cordarone,Atamsil),为苯骈呋喃衍生物(其化学结构式如下),早在1964年就发现它有相当强的平滑肌松弛和冠状动脉的扩张作用,用于治疗心绞痛,疗效良好。以后发现其具有抗心律失常特性,而口服给药对正常或衰竭的心肌无明显的负性肌力作用,1973年 coumel 等及随后 Rosenbaum 等报告乙胺碘呋酮用于临床治疗包括预激综合征合并心律失常和心肌梗塞后心室壁瘤伴室性心动过速或心室颤动
Amiodarone (cordarone, Atamsil) is a benzofuran derivative (the chemical structure of which is as follows). As early as 1964, it found that it has quite strong effects of smooth muscle relaxation and coronary dilatation for the treatment of angina pectoris , Good effect. Later found to have anti-arrhythmic properties, and oral administration of normal or failed myocardium no negative negative effects, such as coumel in 1973 and then Rosenbaum et al reported that amiodarone for clinical treatment including pre-excitation synthesis Syndrome with arrhythmia and myocardial infarction after ventricular aneurysm with ventricular tachycardia or ventricular fibrillation