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目的探讨新疆地区新生儿先天性甲状腺功能低下症(CH)的发病情况,以便做到早确诊、早治疗。方法新生儿出生后72h,采足跟血,制成干血滤纸片,用时间荧光分辨法检测干血片中促甲状腺素(TSH)的水平,TSH≥9μU/ml为阳性,阳性病人召回采静脉血,用化学发光法测甲功五项(TSH、FT3、FT4、T3、T4浓度)而确诊。确诊患儿立即口服甲状腺素片或优甲乐进行治疗并定期监测其体格和智力发育情况。结果自2003年1月至2010年12月共筛查45499例新生儿,确诊31例,检出率为1/1468,明显高于全国平均水平。结论新生儿促甲状腺功能低下症的筛查和治疗,是减少出生缺陷,提高人口素质的重要措施。
Objective To investigate the incidence of congenital hypothyroidism (CH) in newborns in Xinjiang in order to achieve early diagnosis and early treatment. Methods Twenty-two hours after birth, hematopoietic stem cells were collected and blood was collected to determine the level of thyroid-stimulating hormone (TSH) in dried slices. The TSH≥9μU / ml was positive and the positive patients were recalled Venous blood, using chemiluminescence method measured five items (TSH, FT3, FT4, T3, T4 concentration) and confirmed. Children diagnosed immediately oral thyroxine tablets or euthyrox to treat and regularly monitor their physical and mental development. Results A total of 45,499 newborns were screened from January 2003 to December 2010 and 31 cases were confirmed. The detection rate was 1/1468, which was significantly higher than the national average. Conclusion screening and treatment of neonatal hypothyroidism is an important measure to reduce birth defects and improve the quality of the population.