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目的为研究内蒙地区汉族人群人类白细胞抗原(human leukocyte antigen,HLA)DRB1基因与CML白血病的相关性。方法采用Luminex流式技术-序列特异性寡核苷酸探针反向杂交(flow cytometry-sequence specific oligonucle-otide probe,FLOW-SSOP)方法对内蒙地区39例慢性粒细胞白血病chronic myeloid leukemia,CML)患者HLA-DRB1等位基因多态性进行分析,以北方地区健康群体资料作为正常对照。结果在HLA-DRB1等位基因中,CML白血病组中DRB1*1001,*16XX等位基因频率高于对照组(0.593%,0.603%,P<0.05)。结论 DRB1*1001,DRB1*16XX等位基因与CML相关联,可能是易感基因。
Objective To investigate the relationship between human leukocyte antigen (HLA) DRB1 gene and CML leukemia in Han nationality in Inner Mongolia. Methods Flow cytometry-sequence specific oligonucleotide probe (FLOW-SSOP) was used to detect the expression of CML in 39 cases of chronic myeloid leukemia in Inner Mongolia. Patients with HLA-DRB1 allele polymorphisms were analyzed, healthy population data in the northern region as a normal control. Results Among HLA-DRB1 alleles, the frequencies of DRB1 * 1001 and * 16XX alleles in CML leukemia group were higher than those in control group (0.593%, 0.603%, P <0.05). Conclusion DRB1 * 1001 and DRB1 * 16XX alleles are associated with CML and may be susceptible genes.