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在妊娠期应用药物时,特别要注意其对胚胎和胎儿的不良反应,选用抗生素时尤需慎重。药物和有关因素可以引起高达60%的先天性畸形,但根据现有资料表明,仅有少数几类抗生素在妊娠期使用是完全有害的。妇女妊娠时不能应用下列抗生素:氨基甙类如庆大霉素、链霉素、妥布霉素等;抗真菌抗生素如二性霉素B、5-氟胞嘧啶、灰黄霉素等;5-硝基咪唑类如甲硝哒唑等;多粘菌素类如多粘菌素B、多粘菌素E等;四环素类如强力霉素、二甲胺四环素、四环素等及万古霉素。氨基甙类能通过胎盘,妊娠
In the application of drugs during pregnancy, with particular attention to its adverse effects on embryos and fetuses, especially when using antibiotics. Drugs and related causes up to 60% of congenital malformations, but based on available data, only a few classes of antibiotics are completely harmful to use during pregnancy. Pregnant women can not apply the following antibiotics: aminoglycosides such as gentamicin, streptomycin, tobramycin and the like; antifungal antibiotics such as amphotericin B, 5-fluorocytosine, griseofulvin, etc .; 5 - nitroimidazoles such as metronidazole; polymyxins such as polymyxin B, polymyxin E; tetracyclines such as doxycycline, minocycline, tetracycline and vancomycin. Amino glycosides through the placenta, pregnancy