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目的：探讨健乳灵治疗乳腺增生病的疗效和对性激素的调节机理。方法：观察健乳灵治疗前后乳腺增生病的临床变化及血清性激素变化。动物实验通过病理、电镜、放射免疫（ＲＩＡ）等法观察健乳灵治疗乳腺增生病的疗效和性激素的变化。结果：健乳灵能治疗乳腺增生病，治疗组临床治愈率为７２５％，总有效率为９０８％，与对照组比较有显著性差异（Ｐ＜００１），而且有调节性激素水平的作用；雌二醇（Ｅ２）和垂体催乳素（ＰＲＬ）明显降低（均Ｐ＜００５）；而孕酮（Ｐ）和睾酮（Ｔ）则有回升（均Ｐ＜００５）；促卵泡成熟激素（ＦＳＨ）和促黄体生成素（ＬＨ）改变无显著性差异（均Ｐ＞００５）。健乳灵对实验性乳腺增生大鼠有明显防治作用，能调整大鼠体内的性激素分泌；对实验性乳腺增生大鼠的乳腺结构也有明显的改善作用（Ｐ＜００１）。结论：健乳灵治疗乳腺增生病有显著的临床疗效，并能调整机体内源性激素水平，改善乳腺慢性囊性增生的病变过程。
Objective: To investigate the efficacy and therapeutic mechanism of sex hormones in the treatment of hyperplasia of mammary glands. Methods: To observe the clinical changes of hyperplasia of mammary gland before and after treatment with Jianmilling and the changes of serum sex hormones. Animal experiments were conducted to observe the efficacy of Jianmiling in the treatment of mammary gland hyperplasia and changes in sex hormones by pathology, electron microscopy, and radioimmunoassay (RIA). RESULTS: In the treatment of hyperplasia of mammary glands, Jianmil Lingling had a clinical cure rate of 72.5% and a total effective rate of 90.8%. There was a significant difference from the control group (P<0. 01), and there were adjustments. Efficacy of sex hormone levels; estradiol (E2) and pituitary prolactin (PRL) decreased significantly (all P<005); progesterone (P) and testosterone (T) rebounded (both P<005 There was no significant difference in FSH and LH (all P>005). Jianlingling has obvious preventive and therapeutic effects on rats with experimental hyperplasia of mammary glands, and can regulate the secretion of sex hormones in rats; it also has obvious improvement effect on the mammary gland structure of experimental mammary hyperplasia rats (P<001). Conclusion: Jianmiling has a significant clinical effect on the treatment of hyperplasia of mammary glands, and can regulate the level of endogenous hormones and improve the pathological process of chronic cystic hyperplasia of the breast.