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本世纪初,Paul Ehrlich设想利用对特定器官有亲和性的物质作为载体,将药物或毒素与载体结合,然后带至病灶处以破坏靶细胞,他将此类药物称为“魔弹”,即“导弹型药物”或“定向药物”。50年代,Dav-id pressman 提出抗体可作为此类药物的载体。此后20余年中,许多学者对细菌毒素及植物毒素杀死细胞(?)机制研究取得了进展,如白喉毒素(DT)灭活EF-2、蓖麻毒素(RT)能使核糖体605亚基灭活,均可使蛋白质合成抑制而导致细胞死亡。近年,随着抗体纯化技术的进步以及单克隆抗体(McAb)的问世,使“导弹型药物”—免疫毒素得以延生。免疫毒素的载体为纯
In the beginning of this century, Paul Ehrlich envisaged the use of substances that have affinity for specific organs as a carrier to bind drugs or toxins to carriers and then to lesions to destroy target cells. He refers to such drugs as “magic bullets” “Missile-type drug” or “targeted drug.” In the 1950s, Dav-id pressman suggested that antibodies may serve as a carrier for such drugs. Over the past 20 years or more, many scholars have made advances in the mechanism of bacterial toxins and plant toxins killing cells (?), Such as diphtheria toxin (DT) inactivation of EF-2, ricin (RT) Inactivation, can make the protein synthesis inhibition and lead to cell death. In recent years, with the progress of antibody purification technology and the advent of monoclonal antibodies (McAbs), the “missile-type drug”, an immunotoxin, has been extended. The immunotoxin carrier is pure