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采用束缚-水浸法建立大鼠应激性溃疡模型,以胃粘膜缺损程度和胃内出血量改变为指标,研究硫糖铝及营养液[1.39mmol/L(25%)葡萄糖液,1.39mmol/L葡萄糖液加能量合剂,脂肪乳剂],对大鼠应激性溃疡形成中的影响。结果表明:硫糖铝、1.39mmol/L葡萄糖液对大鼠应激性溃疡具有显著预防作用,而1.39mmol/L葡萄糖液加能量合剂和脂肪乳剂均无预防作用。
The model of stress ulcer in rats was established by binding-water immersion method. The indexes of gastric mucosa defect and intragastric bleeding were taken as indices to study the effects of sucralfate and nutrient solution [1.39mmol / L (25%) glucose solution, 1.39mmol / L glucose solution plus energy mixture, fat emulsion] on the formation of stress ulcer in rats. The results showed that sucralfate and 1.39 mmol / L glucose solution had significant preventive effect on stress ulcer in rats, but no effect of 1.39 mmol / L glucose solution plus fat mixture and lipid emulsion were found.