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过去的20年间,乏氧细胞放射增敏剂的研究一直引起人们相当大的兴趣,它的发展将有助于解决肿瘤乏氧细胞对射线的抗性而致肿瘤放疗治愈率低的难题,也可以用于化疗增敏。已发现一些类型化合物有放射增敏作用,但是研究较多、最有希望发展成为临床使用药物的目前有三类,即硝基杂环类,有机-N-氧化物类和醌类。一、硝基杂环类 20年前发现硝基杂环类具有选择性乏氧细胞增敏作用。最初对对硝基苯乙酮类化合物的研究表明,对乏氧细胞的增敏活性为硝基芳环类化合物所特有。其后,对多种硝
In the past 20 years, the research of hypoxic cell radiosensitizer has drawn considerable interest. Its development will help to solve the problem that tumor hypoxia cells have resistance to radiation and cause low cure rate of tumor radiotherapy. Can be used for chemotherapy sensitization. Some types of compounds have been found to have radiosensitizing effects, but there are currently more studies on the three most promising drugs currently in clinical use, namely nitroheterocycles, organic N-oxides and quinones. First, the nitro-heterocyclic 20 years ago found that nitro-heterocyclic ring with selective hypoxic cell sensitization. Initial studies of p-nitroacetophenones have shown that the sensitizing activity to hypoxic cells is characteristic of nitroaromatic compounds. After that, a variety of nitrate