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目的观察山莨菪碱(654-2)减少红霉素副作用的效果。方法对145例下呼吸道感染患儿按开始使用红霉素的日期(单日为治疗组,双日为对照组)随机分为两组,治疗组(75例)用654-2注射液与红霉素注射液混合于同一液体中静脉,对照组(70例)单纯给予红霉素静滴,观察两组主要副作用(恶心、呕吐、腹痛、腹泻及注射部位疼痛)的发生率,以及因红霉素副作用而被迫停药的发生率。结果治疗组副作用发生率及被迫停药发生率均低于对照组,差异有显著性意义。结论654-2能减少红霉素的副作用,值得儿科临床推广应用。
Objective To observe the effect of anisodamine (654-2) in reducing the side effects of erythromycin. Methods One hundred and forty-five children with lower respiratory tract infection were randomly divided into two groups according to the date of starting erythromycin (single-day treatment group and double-day control group). The treatment group (75 cases) Injecting the intravenous injection of mycophenolate mofetil in the same liquid, the control group (70 patients) were given erythromycin intravenously only to observe the main side effects (nausea, vomiting, abdominal pain, diarrhea and injection site pain) in both groups, Side effects of the drug were forced to stop the incidence of. Results The incidence of side effects and discontinuation of treatment in treatment group were lower than those in control group, the difference was significant. Conclusion 654-2 can reduce the side effects of erythromycin, it is worth pediatric clinical application.