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目的考察注射用头孢拉定分别与板蓝根和聚肌胞注射液的配伍稳定性。方法采用高效液相色谱法测定配伍液中头孢拉定8h内的含量变化,同时观察配伍液的外观和pH值的变化。结果注射用头孢拉定与2种药物配伍,头孢拉定的含量在室温下8h内均无明显变化,配伍液的外观澄清,pH值基本稳定。结论室温下8h内注射用头孢拉定分别与上述2种药物配伍基本稳定,可为临床合理用药提供依据。
Objective To investigate the compatibility of Cefradine injection with Radix isatidis and Polymyosine injection. Methods HPLC was used to determine the content of cephradine in the compatibility solution within 8 hours. At the same time, the appearance and pH of the compatibility solution were observed. Results Cefradine injection was compatible with the two drugs. The content of cephradine did not change significantly within 8 hours at room temperature. The appearance of the compatibility liquid was clear and the pH value was basically stable. Conclusion Cefradin injection at 8h at room temperature with the above two drugs were basically stable, can provide a basis for clinical rational use of drugs.