论文部分内容阅读
目的:研究骶神经根对膀胱功能的选择性支配,为临床脊髓损伤(SCI)后的膀胱功能重建及建立实验性人工膀胱动物模型提供依据。方法:对10只SCI的SD大鼠进行硬膜外S1~S4骶神经根电刺激,记录膀胱神经丛动作电位和膀胱平滑肌复合肌肉动作电位变化,同时通过膀胱内插入测压管并经压力换能器记录膀胱内压的变化。结果:SD大鼠的S1~S4骶神经均参与膀胱神经功能支配,其中以S2骶神经最主要,S1、S3骶神经次之,S4骶神经的支配作用最小。结论:不同的骶神经根对膀胱平滑肌的支配效能不同,利用膀胱平滑肌的主要支配神经根进行人工电刺激排尿或通过神经吻合重建人工膀胱反射弧,对提高SCI后的膀胱排尿功能有一定的临床意义。
Objective: To study the selective dominance of sacral nerve root on bladder function and to provide basis for functional reconstruction of bladder after establishing SCI and establishment of experimental artificial bladder animal model. Methods: Eighteen sciatic SD rats were subjected to electrical stimulation of S1 - S4 sacral nerve roots. The changes of action potentials of bladder plexus and bladder muscle were recorded. The bladder was inserted into the piezometer and pressured The device records changes in bladder pressure. Results: The S1 ~ S4 sacral nerves of SD rats were all involved in the function of bladder nerves. The S2 sacral nerves were the most important, the S1 and S3 sacral nerves were the second, and the sacral nerves of S4 were the least. CONCLUSIONS: Different sacral nerve roots have different dominance effects on bladder smooth muscle. Artificial electrical stimulation of urinary bladder by using the dominant nerve root of bladder smooth muscle or rebuilding artificial bladder reflex arc through nerve anastomosis may be helpful in improving urinary bladder function after SCI significance.