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于1992年对宁夏银川市郊区农民乙型肝炎病毒(HBV)感染情况进行了调查,用酶联免疫吸附测定(ELISA)法按年龄不同分层随机抽取1172人同时检测HBsAg、抗-HBs、HBeAg、抗-HBc和抗-HBe五项血清学标志物,结果表明,HBsAg阳性率为7.34%,接近于乙肝高发区下限(8～20%);15～岁、30～岁,40～岁年龄组HBsAg阳性率分别为14.29%、9.74%、12.50%,处于乙肝高发区范围。各项标志物阳性率男女间、回汉族间差异均不显著(P>0.05)。HBsAg、HBeAg、抗-HBc阳性率随年龄增长而升降(x_(10)~2分别为13.66、11.35、8.79,P>0.05),其升降类型相似,高峰年龄组均在18～岁,40～岁年龄组均有不同程度升高。抗-HBs和抗-HBe阳性率有随年龄增长而明显上升趋势(x_(10)~2分别为37.06和56.40,P<0.05;Cox-Stuart升降趋势检验:k=0,n:5,P<0.05);抗～HBs明显升高在20～岁年龄组,较HBV其它血清学标志物推迟一个年龄段。HBV感染率为26.02%,其男女间及回汉族间的差异均不显著(P>0.05),虽未发现随年龄增高趋势(Cox-Stuart检验:k=1,n:5,P>0.05),但年龄组间差异显著(x_(10)~2=72.89,P<0.05),0～岁年龄组HBV感染率最低(2.86%),提示0岁年龄应是乙肝疫苗接种最佳时期。
In 1992, the status of hepatitis B virus (HBV) infection among peasants in suburbs of Yinchuan, Ningxia was investigated. The number of HBsAg, anti-HBs, HBeAg, HBeAg and HBeAg were detected by enzyme-linked immunosorbent assay (ELISA) , Anti-HBc and anti-HBe serological markers, the results showed that the positive rate of HBsAg was 7.34%, close to the lower limit of high incidence of hepatitis B (8 to 20%); 15 to 30 years old, 40 to 40 years of age Group HBsAg positive rates were 14.29%, 9.74%, 12.50%, in the high incidence of hepatitis B area. The positive rate of each marker was not significantly different between male and female, back to Han (P> 0.05). The positive rates of HBsAg, HBeAg and anti-HBc increased with age (x_ (10) ~ 2 = 13.66,11.35,8.79, P> 0.05) Age group have increased to varying degrees. The positive rate of anti-HBs and anti-HBe with age increased significantly (x_ (10) ~ 2 were 37.06 and 56.40, P <0.05; Cox-Stuart ascending and descending trend test: k = 0, n: 5, P <0.05). Anti-HBs increased significantly in 20 ~ age group, which was delayed by one age group compared with other HBV serological markers. HBV infection rate was 26.02%, there was no significant difference between men and women and between Han and Han (P> 0.05). Although the trend was not obvious with age (Cox-Stuart test: k = 1, n: 5, P> 0.05) , But there was significant difference between age groups (x 10 ~ 2 = 72.89, P <0.05). The lowest HBV infection rate was found in 0 ~ age group (2.86%), suggesting that 0-year-old should be the best period for hepatitis B vaccination.