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直至六十年代初,对骨肉瘤的治疗,尽管施行高位截肢或关节离断等根治手术,但85%以上的病例于术后1～2年死于肺转移,5年生存率仅在10～15%左右。近年由于化疗、放疗、免疫化疗的进展与应用,使骨肉瘤的疗效大为提高。一、骨肉瘤治疗的演变1.手术与放射线疗法二十年代Myerding 对拒绝手术的或已形成肺转移的患者,应用放射线作姑息疗法,因效果不佳,未能推广。1930年lansitzen 等研制了超高压X 线以来,才又重新考虑这一疗法。
Until the early 1960s, in the treatment of osteosarcoma, more than 85% of the patients died of lung metastasis 1 to 2 years after the operation, but the 5-year survival rate was only 10 to 10%. About 15%. In recent years, due to the progress and application of chemotherapy, radiotherapy, and immunotherapy, the curative effect of osteosarcoma has been greatly improved. First, the evolution of osteosarcoma treatment 1. Surgery and radiation therapy Myerding in the twenties of patients who refused surgery or have formed lung metastases, the use of radiation as palliative therapy, due to poor results, can not be promoted. In 1930, Lansitzen et al. had reconsidered this therapy since the development of the EHV X-ray.