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本文报告一组较晚期乳腺癌根治术后短期辅助化疗,而远期结果喜人。自1968到1973年凡腋下淋巴结受累在4枚以上、共100例乳腺癌患者,于根治术后均接受为期9月的VPCMF辅助化疗。其中17例另还接受术区补加放疗,但随访结果,有的达8年,反远不如术后单纯化疗者;为此,另有专文论述。73例术后单纯化疗者,其中位无复发生存期竟长达217月,腋下淋巴结转移多于一枚,来自名家报告的中位无复发生有期110月显著延长。不仅如此,8年无病生存率高达68%。闭经与否未见影响效果,说明无化疗袪除性腺作用。化疗方法是五药同时开始,同时结束(强地松用期短属例外);长春新碱(V),每周一次静注35μg/kg,
This article reports a series of short-term adjuvant chemotherapy after radical mastectomy and long-term outcome. From 1968 to 1973, when the axillary lymph nodes were involved in more than 4 cases and 100 cases of breast cancer patients, they received VPCMF adjuvant chemotherapy for 9 months after radical resection. Among them, 17 cases also received additional regional radiotherapy, but the follow-up results, some of up to 8 years, far less than postoperative chemotherapy alone; for this, another special article discusses. Of the 73 patients who received postoperative chemotherapy alone, the recurrence-free survival time was as long as 217 months, and there was more than one axillary lymph node metastasis. The median time from the famous report was significantly longer in 110 months. Not only that, the 8 year disease-free survival rate is as high as 68%. There was no effect of amenorrhea, indicating that no chemotherapy was used to remove the gonads. The chemotherapy was started at the same time as the five drugs, and at the same time ended (except for the short-term use of the prednisone); vincristine (V), once weekly, at 35 μg/kg,