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已在SLE患者发现多种抗核抗体,包括抗dsDNA、ssDNA,多核甙酸、核糖体、dsRNA和ssRNA等抗体.最近,Kanai等报告了一种新的自身抗体:抗聚[二磷酸腺甙(ADP)—核糖]抗体Okolie和Shall经初步研究证实这种抗体对SLE具有特异性.聚(ADP-核糖)是由染色质结合酶,即聚(ADP-核糖)聚合酶作用于烟酰胺腺嘌呤二核甙酸(NAD)而形成的核的聚合体.虽然已有人评论
A variety of antinuclear antibodies, including anti-dsDNA, ssDNA, polyribonucleotides, ribosomal, dsRNA and ssRNA antibodies have been found in SLE patients. Recently, Kanai et al. Reported a new autoantibodies against poly [adenosine diphosphate (ADP) - Ribose] Antibodies Okolie and Shall have demonstrated that this antibody is specific for SLE after a preliminary study.Poly (ADP-ribose) is a compound that acts on nicotinamide adenine by a chromatin-binding enzyme, poly (ADP-ribose) polymerase Purine dinucleotide (NAD) and the formation of nuclear aggregates, although it has been commented