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本文对21例正常新生儿脐血血清和10例肺出血患婴血清C_(1q)、C_4和C_3用单向扩散法作定量分析;对14例正常新生儿脐血血清和全部肺出血患婴血清用交叉免疫电泳法检测C_3裂解产物。21例正常新生儿脐血血清C_(11)、C_4 和 C_3含量(x±SD)分别为 13.3±4.0、17.4±6.3和81.1±25.2mg％。10例肺出血患婴分别为 5.2±2.4、11.7±6.8和 51.2±28.8mg％。两组相比均有明显差异(P<0.001、0.01和 0.01)。14例正常新生儿脐血EDTA血清全部未能检出C_3裂解产物,10例肺出血患婴中 4例检出 C_3裂解产物。表明肺出血患婴存在明显的低补体血症和补体激活。结合10例肺出血患婴中8例存在感染,表明严重感染的肺出血患婴伴有的低补体血症,可能与细菌抗原与相应抗体形成的免疫复合物或细菌抗原直接激活补体,导致补体消耗增加有关。
In this paper, 21 cases of normal neonatal umbilical serum and 10 cases of pulmonary hemorrhage in serum C_ (1q), C_4 and C_3 by one-way diffusion method for quantitative analysis; 14 cases of normal neonates with cord blood serum and total pulmonary hemorrhage Serum C_3 cleavage products were detected by cross-immunoelectrophoresis. Serum levels of C_ (11), C_4 and C_3 (x ± SD) in 21 normal newborns were 13.3 ± 4.0, 17.4 ± 6.3 and 81.1 ± 25.2 mg%, respectively. Infants with pulmonary hemorrhage were 5.2 ± 2.4, 11.7 ± 6.8 and 51.2 ± 28.8 mg%, respectively. There were significant differences between the two groups (P <0.001, 0.01 and 0.01). 14 cases of normal neonatal umbilical blood EDTA serum all failed to detect C_3 lysate, 10 cases of pulmonary hemorrhage in children with C_3 pyrolysis products were detected in 4 cases. Indicated that the infant with pulmonary hemorrhage obvious hypo-hyperlipidemia and complement activation. Combined with 10 cases of pulmonary hemorrhage in infants with infection in 8 cases, indicating severe infection with pulmonary hemorrhage in infants associated with hypo-hyperlipidemia, bacterial antigen and the corresponding antibodies may be formed by immune complexes or bacterial antigen directly activate complement, leading to complement Increased consumption related.