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朊病毒(prion)病是一类神经系统退行性疾病,是prion蛋白从正常态构象(PrP~C)转变为瘙痒态构象(PrP~(Sc))导致的。具有神经细胞毒性的可溶性prion蛋白寡聚体的形成是prion致病过程的重要步骤,其分子机制尚不清楚。林东海教授领导的课题组近年来对prion蛋白寡聚化进行研究,为阐明prion病发病机制和防治prion病提供有价值的信息。
Prion disease is a type of neurodegenerative disease caused by the conversion of prion protein from the normal conformation (PrP-C) to pruritus conformation (PrP ~ (Sc)). The formation of soluble prion protein oligomers with neurocytotoxicity is an important step in prion pathogenesis. The molecular mechanism is not yet clear. In recent years, the research team led by Professor Lin Donghai studied the prion protein oligomerization and provided valuable information for elucidating the pathogenesis of prion disease and prion disease prevention.