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链阳性菌素是一类独特的抗生素 ,它的每一成员至少由两种结构不相关的分子组成 :链阳性菌素A和链阳性菌素B ,两种组分都在核糖体水平抑制蛋白质的合成。它们的伍用对许多分离株表现出协同杀菌作用 ,并且减少产生耐药菌的可能。由链阳性菌素B诱导而获得的耐药性机制与红霉素的相似。链阳性菌素A不受靶标修饰和主动外排的影响 ,两组分在血液中的药动学参数十分相似。组分A和B都能渗入并蓄积在巨噬细胞和实验性心内膜炎的细菌性赘生物中。链阳性菌素类和大环内酯抗生素在结构和生物学上有很大不同 ,主要是链阳性菌素的快速杀菌性能及组分A和B之间很少有交叉耐药性。
Streptogramin is a unique class of antibiotics each of which consists of at least two structurally unrelated molecules: streptogramin A and streptogramin B, both of which inhibit the protein at the ribosome level Synthesis. Their use shows synergistic bactericidal activity against many isolates and their potential for producing resistant bacteria. The drug resistance mechanism induced by streptogramin B is similar to erythromycin. Streptogramin A is unaffected by the target modification and extrinsic efflux, and the pharmacokinetic parameters of the two components in the blood are very similar. Both components A and B infiltrate and accumulate in bacterial neoplasms of macrophages and experimental endocarditis. Streptogramin and macrolide antibiotics in the structure and biology are very different, mainly the rapid bactericidal properties of streptogramin and components A and B there is little cross-resistance.