Isolation and Characterization of 2′-amino-modified RNA Aptamersfor Human TNFα

• 作 者: XinruiYan XuwenGao ZhiqingZhan
• 机 构: StateKeyLaboratoryforMolecularVirologyandGeneticEngineering
• 出 处: 基因组蛋白质组与生物信息学报：英文版
• 发表日期: 2004年1期
• 关键词: HTNFΑ 人肿瘤坏死因子Α 相似法则 RNA 核糖核酸 低聚核苷酸配位子 亲和性 SELEX hTNFα aptamer affinity RNA ELONA

Human tumor necrosis factor α (hTNFα), a pleiotropic cytokine with activities ranging from host defense mechanisms in infection and injury to severe toxicity in septic shock or other related diseases, is a promising target for drug screening. Using the SE