论文部分内容阅读
在现代避孕方法中,甾体避孕药(SC)得到广泛应用。据Standley和Kessler的资料,全世界约有1亿妇女使用这类避孕药物。应用SC后发生肿瘤疾病的危险,促进了这方面的科学研究。已知,妇女的两个主要定位肿瘤—子宫体癌和乳腺癌是激素依赖性的。而外源性激素在这些肿瘤发生中的作用尚未得到彻底研究,已发表的资料也极不一致。这与缺乏标准的方法及一些常见的原因有关。如目前对癌的病因学还缺乏准确认识,对从致癌因子作用到发病之间的潜伏期还未作过研究等。避孕制剂数量之大、应用的配伍和方式以及使用剂量的不同也给问题的解决带来困难。目前已评价了含相当高剂量雌激素和孕激素的SC应用的远期效果,其中很多已停止生产。肯定了在氯地孕酮和其它衍生的17α-
In modern contraceptive methods, steroidal contraceptives (SC) are widely used. According to Standley and Kessler, about 100 million women in the world use such contraceptives. The application of SC after the risk of cancer diseases, and promote scientific research in this area. Known that women’s two main targeted tumors - endometrial cancer and breast cancer are hormone-dependent. The role of exogenous hormones in the development of these tumors has not been thoroughly studied and published data are also very inconsistent. This is related to the lack of standard methods and some common causes. Such as the current etiology of cancer is still a lack of accurate understanding of the role of carcinogens from the onset of the incubation period has not been studied. The large number of contraceptives, the compatibility and mode of application as well as the differences in the dosage used also make it difficult to solve the problem. The long-term effect of SC with relatively high doses of estrogen and progestin has now been evaluated, many of which have ceased to be produced. Affirmed that in the chlormadinone and other derived 17α-