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我们从1979年8月至1981年7月对397例住院的高危妊娠孕妇进行尿雌三醇测定720次.尿E_3低值的发生率为35.01%,主要为重度PIH,PIH合并过期妊娠或慢性高血压,妊娠合并肾脏病及胎儿宫内生长迟缓等。围产儿死亡率(按WHO围产Ⅰ标准)为31.4‰,修正后为19.3‰。尿E_3低值与正常值两组间的围产期病例与死亡率有非常显著的差异(P<0.01)。回顾性分析认为尿E_3值可作为衡量胎儿一胎盘单位功能的一种指标,但作为单一指标来预测高危的后果是不够准确的。尿E_3连续测定基本上有四种类型:上升型,下降型,持续低值及不稳定型。根据尿E_3值的动态变化并/或配合其他试验结果,产科医生在临床治疗和处理方面可作出较为准确的判断以改进高危妊娠的预后。为降低高危妊娠的围产儿病率和死亡率,早期诊断畸胎和妊娠高血压综合症,积极治疗各种可转化的妊娠并发症是十分重要的。
We performed 720 urinary estriol tests on 397 high-risk pregnant women in hospital from August 1979 to July 1981. The incidence of urinary E 3 low was 35.01%, mainly for severe PIH, PIH with expired pregnancy, or chronic Hypertension, pregnancy with kidney disease and fetal growth retardation and so on. The perinatal mortality rate (according to WHO perinatal standard I) was 31.4 ‰, after correction to 19.3 ‰. There was a significant difference in perinatal morbidity and mortality between the two groups of low and normal urine E_3 (P <0.01). Retrospective analysis that urinary E_3 value can be used as a measure of fetal placental function as an indicator, but as a single indicator to predict the consequences of high-risk is not accurate enough. There are basically four types of urine E_3 continuous measurement: rising, falling, sustained low and unstable. Depending on the dynamic changes in urinary E 3 values and / or in combination with other test results, obstetricians can make more accurate judgments in clinical treatment and management to improve the prognosis of high-risk pregnancies. To reduce perinatal morbidity and mortality in high-risk pregnancies, early diagnosis of teratogenic and pregnancy-induced hypertension syndromes is of paramount importance in actively treating various transformable pregnancy complications.