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目的:分析研究地特胰岛素联合二甲双胍应用于治疗2型糖尿病的临床疗效和评价其安全性。方法:选取我院收治的64例2型糖尿病患者进行回顾分析,64例患者中,单独应用地特胰岛素治疗2型糖尿病的有32例,分为对照组;联合应用地特胰岛素和二甲双胍治疗2型糖尿病的有32例,分为治疗组。两组患者均从我院收治的2型糖尿病患者中随机抽取。两组患者接收治疗3个月后,比较两空腹血糖值(FPG)、餐后血糖值(2h PBG)、糖化血红蛋白(Hb Alc)和体重指数(BMI)等。结果:两组患者接受治疗后,空腹血糖值(FPG)、餐后血糖值(2h PBG)、糖化血红蛋白(Hb Alc)均有明显下降,治疗前后有显著性差异。但治疗组效果更明显。结论:地特胰岛素联合二甲双胍治疗2型糖尿病比单独使用地特胰岛素治疗2型糖尿病效果更佳。
OBJECTIVE: To analyze and evaluate the clinical efficacy and the safety of insulin detemir plus metformin in the treatment of type 2 diabetes mellitus. Methods: A total of 64 patients with type 2 diabetes mellitus admitted to our hospital were retrospectively analyzed. Of the 64 patients, 31 patients with type 2 diabetes treated with insulin detemir alone were divided into two groups: control group, combination of insulin detemir and metformin 32 cases of type diabetes, divided into treatment group. Two groups of patients were randomly selected from patients with type 2 diabetes treated in our hospital. After two months of treatment, the two groups received two fasting blood glucose (FPG), postprandial blood glucose (2h PBG), Hb Alc, and body mass index (BMI). Results: After treatment, fasting blood glucose (FPG), postprandial blood glucose (2h PBG) and Hb Alc were significantly decreased in both groups, with significant difference before and after treatment. But the treatment group effect is more obvious. CONCLUSION: Combination of insulin detemir and metformin is more effective than type 2 diabetes mellitus in the treatment of type 2 diabetes mellitus.