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目的探讨炎症反应在阻塞型睡眠呼吸暂停低通气综合征(OSAHS)发病中的作用及其临床意义。方法应用酶联免疫吸附法检测OSAHS患者血清白细胞介素-6(IL-6)水平,以及持续气道正压通气(CPAP)对中、重度OS-AHS患者血清IL-6水平的影响。结果OSAHS患者血清IL-6水平显著升高,中、重度患者经CPAP治疗3个月后,血清IL-6水平较治疗前显著降低。结论CPAP治疗可能通过降低OSAHS患者血清IL-6水平,抑制OSAHS炎症反应,从而降低OSAHS患者心脑血管疾病的发病率
Objective To investigate the role of inflammation in the pathogenesis of obstructive sleep apnea-hypopnea syndrome (OSAHS) and its clinical significance. Methods Serum interleukin-6 (IL-6) levels in patients with OSAHS and the effect of continuous positive airway pressure (CPAP) on serum IL-6 levels in patients with OSAHS were measured by enzyme-linked immunosorbent assay. Results Serum IL-6 levels were significantly increased in patients with OSAHS. Serum levels of IL-6 in moderate and severe patients after 3 months of CPAP treatment were significantly lower than those before treatment. Conclusion CPAP treatment may reduce the incidence of cardiovascular and cerebrovascular diseases in patients with OSAHS by decreasing serum IL-6 levels and OSAHS inflammatory response in patients with OSAHS