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目的:观察晚期宫颈癌患者同步放化疗前后证候变化。方法:采用前瞻性和回顾性相结合的流行病学研究方法,对诊断晚期宫颈癌初次接受放化疗的患者进行放化疗前后证候病机变化的对照研究。结果:①临床各证型(肝郁气滞、肝肾阴虚、脾肾阳虚、湿热瘀毒)放化疗前与首次放化疗后1周、第2次放化疗后1周、首次放化疗后3个月、第2次放化疗后3个月的证候构成比比较,差异均有显著性意义(P<0.05)。②晚期宫颈癌患者放化疗前后面色变化比较,面色白放化疗治疗后各时间调查点与放化疗治疗前比较,差异有显著性意义(P<0.05)。③晚期宫颈癌患者放化疗前后舌色变化观察,舌质(淡红、红、黯红、淡白、淡黯)、舌苔(薄白苔、白腻苔、白厚苔、黄腻苔、剥少苔)构成比放化疗前与首次放化疗后1周、第2次放化疗后1周、首次放化疗后3个月、第2次放化疗后3个月相比较,差异均有显著性意义(P<0.05)。结论:同期放化疗前后各证型不同,则舌质、舌苔的变化也不同,可为临床治疗提供参考依据。
Objective: To observe the changes of syndromes of patients with advanced cervical cancer before and after concurrent chemoradiotherapy. Methods: A prospective and retrospective epidemiological study was conducted to evaluate the pathogenesis of radiotherapy and chemotherapy before and after radiotherapy and chemotherapy in patients with advanced cervical cancer. Results: ① The clinical syndromes (liver qi stagnation, liver and kidney, spleen and kidney yang, damp heat stasis) before radiotherapy and chemotherapy and radiotherapy and chemotherapy after 1 week, 2 weeks after radiotherapy and chemotherapy for the first time, the first radiotherapy and chemotherapy After 3 months, the second 3 months after radiotherapy and chemotherapy compared to the constitution of the syndromes, the differences were significant (P <0.05). (2) Compared with the patients before radiotherapy and chemotherapy, the differences of the facial color in patients with advanced cervical cancer before and after radiotherapy and chemotherapy were statistically significant (P <0.05). (3) The changes of tongue color of patients with advanced cervical cancer before and after chemoradiotherapy were observed. The constitution of tongue (reddish, reddish, dark red, pale white, pale darkness), tongue (thin white moss, greasy moss, white thick moss, yellow greasy moss, Before radiotherapy and chemotherapy 1 week after the first radiotherapy and chemotherapy, 1 week after the second radiotherapy and chemotherapy, 3 months after the first radiotherapy and chemotherapy, and 3 months after the second radiotherapy and chemotherapy, the differences were significant (P <0.05 ). Conclusion: Before and after radiotherapy and chemotherapy of different syndromes, the tongue, tongue changes are also different, which can provide a reference for clinical treatment.