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本文对40 a以下、60 a以上两组各4例男性做了po安定后的药代动力学指标测定。受试者均无肝功能损害,受试前1 wk内未使用过安定类药物,无肝药酶抑制剂、促进剂使用史,无胃肠功能异常等影响药物吸收的因素。药品为北京第三制药厂产品,以安定1 mg·12 kg~(-1)体重空腹po。服药前后使用指触仪测定受试者反应程度。于服药后30 min,60 min,90 min,3 h,24 h,48 h,72 h,100 h取血,并收集相应时间段内全部尿样,标本经处理后用高效液相色谱仪及TDX分别测定血清中安定药物原型、代谢产物去甲安定及尿内去甲羟安定葡萄
This article for 40 a, 60 a two groups of four men after po stability after pharmacokinetic determination. None of the subjects had liver damage, and no antipsychotic drugs, no hepatic drug inhibitors, no history of accelerating agent use, no gastrointestinal dysfunction, and other factors that affected drug absorption were not used within 1 wk before the test. Pharmaceutical products for the Beijing No. 3 Pharmaceutical Factory, to stabilize 1 mg · 12 kg ~ (-1) weight fasting po. Before and after taking the drug using a finger touch instrument to measure the degree of response of the subjects. Blood samples were taken at 30 min, 60 min, 90 min, 3 h, 24 h, 48 h, 72 h, 100 h after taking the medicine. All the urine samples were collected during the corresponding time period. The samples were processed and characterized by high performance liquid chromatography TDX were measured in serum antipsychotic prototype, methotrexate metabolites and methotrexate in urine