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目的探讨IL-10以及TGF-β1在妊娠期免疫性血小板减少性紫癜(ITP)及妊娠期血小板减少症(GT)发病中的作用。方法以剖宫产分娩的14例妊娠期ITP患者以及17例妊娠期GT患者为研究对象,并以同期24例剖宫产分娩的健康孕妇为对照组。采用ELISA法检测3组母血、脐血中TGF-β1、IL-10的浓度,比较妊娠期ITP组、GT组母血与脐血中TGF-β1、IL-10的浓度,并分析TGF-β1及IL-10与母血血小板、新生儿血小板计数的相关性。结果 3组母血的TGF-β1、IL-10浓度比较无统计学差异(P>0.05),3组脐血中IL-10浓度差异无统计学意义(P>0.05),妊娠期ITP组脐血中TGF-β1浓度与GT组及对照组脐血比较无统计学差异(P>0.05),GT组脐血TGF-β1浓度较对照组升高。在妊娠期ITP组及GT组中,母血、脐血中TGF-β1、IL-10浓度与母体及新生儿血小板水平无明显相关性(P>0.05)。结论 TGF-β1、IL-10在妊娠期ITP及GT发病中的作用可能与非妊娠期ITP不同,TGF-β1、IL-10在母血及脐血中的浓度与血小板水平无相关性。
Objective To investigate the role of IL-10 and TGF-β1 in the pathogenesis of gestational immune thrombocytopenic purpura (ITP) and gestation thrombocytopenia (GT). Methods Fourteen pregnant women with ITP who were delivered by cesarean section and 17 gestational GT patients were enrolled in this study. Twenty-four healthy pregnant women delivered by cesarean section in the same period were taken as control group. The concentrations of TGF-β1 and IL-10 in maternal blood and umbilical cord blood of three groups were detected by ELISA. The levels of TGF-β1 and IL-10 in maternal serum and cord blood of gestational ITP group, GT group were compared. β1 and IL-10 and maternal platelet, neonatal platelet count correlation. Results There was no significant difference in the concentrations of TGF-β1 and IL-10 between the three groups (P> 0.05). There was no significant difference in the concentrations of IL-10 between the three groups (P> 0.05) There was no significant difference in TGF-β1 concentration between the two groups (P> 0.05). The concentration of TGF-β1 in cord blood of GT group was higher than that of control group. In pregnant ITP group and GT group, the concentrations of TGF-β1 and IL-10 in maternal blood and umbilical cord blood had no significant correlation with the levels of maternal and neonatal platelets (P> 0.05). Conclusion The effect of TGF-β1 and IL-10 in ITP and GT during pregnancy may be different from that in non-pregnant ITP. The concentrations of TGF-β1 and IL-10 in maternal blood and umbilical cord blood are not correlated with platelet levels.