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目的探讨南宁市妇女宫颈上皮细胞中23种人乳头状瘤病毒基因型别的感染状况,为预防HPV感染及临床治疗提供参考意见。方法采集2012年1月-2014年8月的2 409例妇女宫颈脱落上皮细胞标本,采用PCR-反向点杂交法检测HPV,将筛查人群分为7个年龄段,分别计算HPV各个型别的感染率。结果有648例妇女感染了HPV病毒,感染率为26.90%,其中以>50岁者感染率最高,为38.89%;23个型别均有检出,其中以52型最多,感染率为19.91%,其次为16型,感染率为16.20%;同时,检出多重感染174例,检出率为7.22%。结论南宁地区人乳头状瘤病毒感染率较高且基因型多样,以52型、16型常见,同时存在多重感染;HPV基因分型检测对于宫颈癌及其癌前病变的发现、预防和治疗有重要意义,应加强宣传宫颈癌的防治知识和普查力度。
Objective To investigate the genotypes of 23 human papilloma virus (HPV) in cervical epithelial cells of women in Nanning and to provide reference for prevention of HPV infection and clinical treatment. Methods From January 2012 to August 2014, 2 409 cases of cervical exfoliated epithelial cells from women were collected. HPV was detected by PCR-reverse dot blot hybridization. The screening population was divided into seven age groups, and the HPV types The infection rate. Results 648 women were infected with the HPV virus, the infection rate was 26.90%, of which the highest infection rate was 38.89% in> 50 years old; 23 types were detected, of which 52 was the most, the infection rate was 19.91% , Followed by 16, the infection rate was 16.20%; the same time, detected multiple infections in 174 cases, the detection rate was 7.22%. Conclusion The prevalence of human papilloma virus in Nanning is high and its genotype is diverse. It is common in type 52 and type 16 with multiple infections simultaneously. The detection, prevention and treatment of cervical cancer and its precancerous lesions by HPV genotyping Significance, cervical cancer should strengthen awareness of prevention and treatment knowledge and census efforts.