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目的:探讨血清心肌酶活性测定在新生儿窒息中的临床应用价值。方法:测定214例窒息新生儿生后24 h内血清天门冬氨酸氨基转移酶(AST)、肌酸激酶(CK)、肌酸激酶同功酶(CK-MB)水平并进行分析。结果:窒息新生儿心肌酶谱活性增高,重度窒息组CK及CK-MB水平均明显高于轻度窒息组(P<0.05)。心肌损害总发生率为85.05%,轻度窒息组为83.52%,重度窒息组为92.11%,二者比较差异无统计学意义(P>0.05)。结论:新生儿窒息后可致心肌损害,CK-MB活性增高是新生儿窒息后心肌损害的早期诊断方法之一。
Objective: To investigate the clinical value of serum myocardial enzyme activity determination in neonatal asphyxia. Methods: Serum aspartate aminotransferase (AST), creatine kinase (CK) and creatine kinase isoenzyme (CK-MB) were measured and analyzed in 214 neonates with asphyxia after birth. Results: Asphyxia neonatal myocardial enzyme activity increased, severe asphyxia group CK and CK-MB levels were significantly higher than mild asphyxia group (P <0.05). The total incidence of myocardial damage was 85.05%, mild asphyxia 83.52%, severe asphyxia 92.11%, there was no significant difference between the two groups (P> 0.05). Conclusion: Asphyxia neonatorum can cause myocardial damage, CK-MB activity is one of the early diagnosis of myocardial damage after neonatal asphyxia.