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目的:研究槲皮素-羟丙基-β-环糊精包合物(QUE-HP-β-CD)对柔红霉素(DNR)心脏毒性的保护作用。方法:将实验小鼠分为6组:正常组每天腹腔注射等量生理盐水;DNR组从实验第9~19天每2日1次腹腔注射3 mg·kg~(-1) DNR;包合物不同剂量组于实验第1~17天每日1次分别灌胃50,100,200 mg·kg~(-1)包合物,并于第9天用与DNR组相同的剂量和方式给予DNR;QUE组用100 mg·kg~(-1) QUE代替包合物,其余处理方法与包合物组完全相同。结果:QUE和不同剂量包合物均能抑制小鼠体质量降低,但100~200 mg·kg~(-1)包合物可显著改善DNR所致心肌肥大和心室重构,并使各项心肌酶恢复到正常水平;切片显示100 mg·kg~(-1)包合物能显著改善DNR所致心肌损伤。结论:QUE-HP-β-CD(100 mg·kg~(-1))对抑制DNR所致小鼠心脏毒性效果最好。
Objective: To study the protective effect of Quercetin-hydroxypropyl-β-cyclodextrin inclusion complex (QUE-HP-β-CD) on daunorubicin (DNR) cardiotoxicity. Methods: The experimental mice were divided into 6 groups: the normal group was given intraperitoneal injection of normal saline daily; DNR group was injected intraperitoneally with 3 mg · kg -1 DNR once every 2 days from the 9th day to the 19th day; The different dose groups were administered intraperitoneally with 50, 100, 200 mg · kg -1 inclusion compound on the 1st to 17th day of the experiment and DNR on the 9th day at the same dose and manner as the DNR group. With 100 mg · kg -1 QUE instead of inclusion complex, the rest of the treatment method and inclusion complex exactly the same. Results: Both QUE and different doses of inclusion complex inhibited the body weight of mice, but inclusion of 100-200 mg · kg -1 significantly improved myocardial hypertrophy and ventricular remodeling induced by DNR. Myocardial enzymes returned to normal levels; slices showed that 100 mg · kg -1 inclusion complex could significantly improve the myocardial injury caused by DNR. Conclusion: QUE-HP-β-CD (100 mg · kg -1) has the best effect on inhibiting cardiotoxicity induced by DNR in mice.