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目的:探讨肝细胞生长因子(hepatocyte growthfactor)在视网膜脱离后增殖性玻璃体视网膜病变(proliferative vitreoretinopathy,PVR)中的作用。方法:酶联免疫吸附法(enzyme-linked im-muno-sorbent assay)测定49 例视网膜脱离(reti-nal detachment)患者视网膜下液(subretinalflu-id,SRF)中肝细胞生长因子的含量。结果:随着PVR程度及玻璃体混浊(vitreousopac-ity)的加重、病程的延长,肝细胞生长因子含量增加,P <0.05,差异有统计学意义。结论:SRF 中肝细胞生长因子改变与视网膜脱离后PVR的发生、发展有密切关系。
Objective: To investigate the role of hepatocyte growth factor in proliferative vitreoretinopathy (PVR) after retinal detachment. Methods: The levels of hepatocyte growth factor in subretinal fluid (SRF) of 49 patients with reti-nal detachment were determined by enzyme-linked immunosorbent assay (ELISA). Results: With the severity of PVR and vitreous opacity, prolonged course of disease, the content of hepatocyte growth factor increased, P <0.05, the difference was statistically significant. Conclusion: The change of hepatocyte growth factor in SRF is closely related to the occurrence and development of PVR after retinal detachment.