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目的研究不同传播途径感染的艾滋病病毒感染者/艾滋病病人(HIV/AIDS病人),在相同CD4水平时的临床表现及中医药干预的疗效。方法通过回顾性研究的方法,选取初诊未用过任何治疗药物、CD4细胞在200～600个/μl、年龄无显著性差异的病人,分为经静脉吸毒(IDU)感染组和经性和原因不明(STU)感染组。根据中医辨证原则给予中药扶正解毒,观测试验前及服中药一年后CD4细胞的绝对值、临床症状体征积分、KPS评分。结果两组病人治疗前、后对比,CD4细胞绝对值组的差异无统计学意义(P>0.05);经过1年中药治疗后,两组病人CD4细胞数有所上升,但与治疗前比差异无统计学意义(P>0.05);治疗后两组CD4细胞数的差异亦无统计学意义(P>0.05)。治疗前入组病人症状体征积分两组之间差异有统计学意义,症状体征积分IDU组明显高于STU组(P<0.05);经过中医药辨证治疗1年后,两组病人症状体征积分明显下降,与治疗前比差异有统计学意义(P<0.01),两组之间治疗后比差异有统计学意义(P<0.01)。治疗前两组病人卡氏评分差异有统计学意义(P<0.05),IDU组明显低于STU组(P<0.05);经过1年治疗后,卡氏评分较治疗前明显升高(P<0.05),STU组评分高于IDU组。结论不同传播途径导致的HIV/AIDS病人,在CD4计数相同的情况下,症状体征和KPS评分会有差异,IDU感染者病情表现会更加严重。不同传播途径导致的HIV/AIDS病人,应用中药都可能起到治疗效果。
Objective To study the clinical manifestations of HIV / AIDS patients (HIV / AIDS patients) infected by different routes of transmission, the same CD4 level and the efficacy of Chinese medicine intervention. Methods A retrospective study was conducted to select patients who did not receive any treatment for newly diagnosed cases and whose CD4 cell count was between 200 and 600 cells / μl with no significant difference in age. The patients were divided into IDU group and sex and cause Unknown (STU) infection group. According to the principle of traditional Chinese medicine to give positive detoxification, observed before and after taking traditional Chinese medicine one year after the absolute value of CD4 cells, clinical symptoms and signs score, KPS score. Results Before and after treatment, there was no significant difference in CD4 cell absolute value between the two groups (P> 0.05). After one year of traditional Chinese medicine treatment, CD4 cell number increased in both groups, but the difference was statistically significant There was no statistical significance (P> 0.05). There was no significant difference in the number of CD4 cells between the two groups after treatment (P> 0.05). Symptoms and signs of patients before treatment into the group were statistically significant differences between the two groups, symptoms and signs integral IDU group was significantly higher than the STU group (P <0.05); after 1 year of traditional Chinese medicine syndrome differentiation, symptom and symptom scores were significantly (P <0.01). The difference between the two groups after treatment was statistically significant (P <0.01). The Karnofsky scores of the two groups before treatment were significantly different (P <0.05), and were significantly lower in IDU group than those in STU group (P <0.05). After one year treatment, the Karnofsky scores were significantly higher than those before treatment (P < 0.05). The score of STU group was higher than that of IDU group. Conclusion HIV / AIDS patients caused by different routes of transmission have different symptoms and signs and KPS scores in the case of the same CD4 count, and the performance of IDU infected persons will be more serious. Different routes of transmission caused by HIV / AIDS patients, the application of traditional Chinese medicine may play a therapeutic effect.